Lescheríchia coli productora de shigatoxines (STC, de l'anglès shiga toxine Escherichia coli) és un bacteri productor de potents toxines i responsable d'algunes intoxicacions alimentàries causants de colitis hemorràgiques i -en casos greus- de la síndrome hemolítica i urèmica, la principal causa d'insuficiència renal aguda en nens petits. Es coneixen múltiples soques del bacteri, no totes elles amb la mateixa virulència. El seu reservori principal són els remugants, encara que s'han registrat diversos casos d'infeccions humanes associades al contacte amb ocells, gossos o cavalls.

Aquest microorganisme es coneix també amb altres noms, com ara enterohemorrhagic E. coli (EHEC), Shiga-like toxin-producing E. coli (SLTEC o STEC), hemolytic uremic syndrome–associated enterohemorrhagic E. coli (HUSEC) o verocytotoxin o verotoxin-producing E. coli (VTEC).

Shiga fa referència a Kiyoshi Shiga qui descobrí Shigella dysenteriae una de les espècies que formen el gènere Shigella.

Referències

Bibliografia

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Lea, N., Lord, J.M. and Roberts, L.M. (1999) Proteolytic cleavage of the A subunit is essential for maximal cytotoxicity of Escherichia coli O157:H7 Shiga-like toxin-1. Microbiology. 145 (Pt 5): 999-1004. Louise, C.B. and Obrig, T.G. (1995) Specific interaction of Escherichia coli O157:H7 derived Shigalike toxin II with human renal endotheial cells. Journal of Infections diseases. 172: 1397-1401 Ludwig, K., Petric, M., Blanchette, V. and Karmali, M. (1998) Isolated thrombocytopenic purpura associated with infection due to verocytotoxin (Shiga toxin)-producing Escherichia coli serotype O26:H11. Clin Infect Dis. 27: 660-661. Paton, A.W., Srimanote, P., Woodrow, M.C. and Paton, J.C. (2001) Characterization of Saa, a novel autoagglutinating adhesin produced by locus of enterocyte effacement-negative Shiga-toxigenic Escherichia coli strains that are virulent for humans. Infect Immun. 69: 6999-7009. Schuller, S., Frankel, G. and Phillips, A.D. (2004) Interaction of Shiga toxin from Escherichia coli with human intestinal epithelial cell lines and explants: Stx2 induces epithelial damage in organ culture. Cell Microbiol. 6: 289-301. Thorpe, C.M., Smith, W.E., Hurley, B.P. and Acheson, D.W. (2001) Shiga toxins induce, superinduce, and stabilize a variety of C-X-C chemokine mRNAs in intestinal epithelial cells, resulting in increased chemokine expression. Infect Immun. 69: 6140-6147. Vernozy-Rozand, C., Montet, M.P., Bertin, Y., Trably, F., Girardeau, J.P., Martin, C., et al (2004) Serotyping, stx2 subtyping, and characterization of the locus of enterocyte effacement island of shiga toxin-producing Escherichia coli and E. coli O157:H7 strains isolated from the environment in France. Appl Environ Microbiol. 70: 2556-2559.

Enllaços externs

Categoria:Enterobacteriàcies Categoria:Bacteris patògens