Hepatoprotecció o antihepatotoxicitat és la capacitat de prevenir danys al fetge.
Un exemple de medicament hepatoprotector és la silibinina, derivada del card marià i altres espècies del seu gènere Silybum que inhibeixen selectivament la formació des leucotriens per part de les cèl·lues de Kupffer.Inhibition of Kupffer cell functions as an explanation for the hepatoprotective properties of silibinin. Dehmlow, Carola; Erhard, Jochen; De Groot, Herbert. Hepatology (1996), 23(4), 749-54.
Plantes medicinals potencialment hepatoprotectores Oli d'ametllaJia X.-Y., Zhang Q.-A., Zhang Z.-Q., Wang Y., Yuan J.-F., Wang H.-Y., Zhao D."Hepatoprotective effects of almond oil against carbon tetrachloride induced liver injury in rats" Food Chemistry 2011 125:2 (673-678) Amomum xanthoidesWang J.-H., Shin J.-W., Kim H.-G., Hye-Jung P., Choi M.K., Son C.-G."Hepatoprotective and antioxidant effects of ethyl acetate soluble fraction of Amomum xanthoides Hepatology International 2010 4:1 (281-282) Arctium lappaLin S.C., Lin C.H., Lin C.C., Lin Y.H., Chen C.F., Chen I.C., Wang L.Y. Hepatoprotective effects of Arctium lappa Linne on liver injuries induced by chronic ethanol consumption and potentiated by carbon tetrachloride. Journal of biomedical science 2002 9:5 (401-409) Astragalus membranaceusChien C.-F., Wu Y.-T., Tsai T.-H."Biological analysis of herbal medicines used for the treatment of liver diseases" Biomedical Chromatography 2011 25:1 (21-38) Xicoira Cichorium intybusTabassum N., Qazi M.A., Shah A., Shah M.Y. Curative potential of Kashni (Cichorium intybus Linn.) extract against carbon tetrachloride induced hepatocellular damage in rats Pharmacologyonline 2010 2 (971-978) Curcuma longa Cajanus indicus,Sarkar K., Sil P.C. Attenuation of acetaminophen-induced hepatotoxicity in vivo and in vitro by a 43-kD protein isolated from the herb Cajanus indicus L Toxicology Mechanisms and Methods 2007 17:6 (305-315Manna P., Sinha M., Sil P.C. A 43 kD protein isolated from the herb Cajanus indicus L attenuates sodium fluoride-induced hepatic and renal disorders in vivo Journal of Biochemistry and Molecular Biology 2007 40:3 (382-395) Centella asiaticaHaleagrahara N., Chakravarthi S., Kumar P. A study of protective effect of centella asiatica in 1-methyl-4phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced liver injury Haleagrahara N., Chakravarthi S., Kumar P. Hepatology International 2009 3:1 (196-197) Coccinia indica'Rao G.M.M., Vijayakumar M., Rao Ch.V., Rawat A.K.S., Mehrotra S. Hepatoprotective effect of Coccinia indica against CCl4 induced hepatotoxicity Natural Product Sciences 2003 9:1 (13-17) EcliptaXu R.-M., Deng K.-M., Lu Y.,"Studies on strengthening and restoring effects and hepatoprotective effect of Eclipta" Journal of Shanghai Jiaotong University (Medical Science) 2009 29:10 (1200-1204 Flickingeria fimbriataDatta G.K., Chakrabartya M., Ghosh S., Debnath P.K. Hepatoprotective effect of Desmotrichum fimbriatum Bl. in mice with carbon tetrachloride-induced liver damage' Biomedical Research 2002 13:2-3 (81-84) Ganoderma lucidumWang X., Zhao X., Li D., Lou Y.-Q., Lin Z.-B., Zhang G.-L.Effects of Ganoderma lucidum polysaccharide on CYP2E1, CYP1A2 and CYP3A activities in BCG-Immune hepatic injury in rats Biological and Pharmaceutical Bulletin 2007 30:9 (1702-1706 Regalèssia ,Glycyrrhiza glabraChoi H.-J., Lee W.-J., Park S.-H., Song B.-W., Kim D.-H., Kim N.-J. Studies on the processing of crude drugs(IX) - Preparing standardization and regulation of stir-frying Glycyrrhzia root(1) Korean Journal of Pharmacognosy 2005 36:3 (209-219 Halenia ellipticaHuang B., Ban X., He J., Zeng H., Zhang P., Wang Y. Hepatoprotective and antioxidant effects of the methanolic extract from Halenia elliptica Journal of Ethnopharmacology 2010 131:2 (276-281) (herba medicinal tibetana) Kalopanax pictus?Hyun T.K., Kim J.-S."The pharmacology and clinical properties of Kalopanax pictus" Journal of Medicinal Plant Research 2009 3:9 (613-620) Murraya koenigii Nymphaea stellataSoni N., Ahmed B., Upadhyay R."Nymphasterol, a new steroid from nymphaea stellata Verma A.", Medicinal Chemistry Research 2010 19 SUPPL. 1 (S47-S48) Ocimum sanctum Paeonia lactiflora Pergularia daemiaIn-vitro evaluation of hepatoprotecttve activity of Pergularia daemia Forsk Sureshkumar S.V., Mishra S.H. Pharmacognosy Magazine 2008 4:16 (298-302)Karthishwaran K., Mirunalini S."Therapeutic potential of Pergularia daemia (Forsk.): The ayurvedic wonder" International Journal of Pharmacology 2010 6:6 (836-843)Sureshkumar S.V., Mishra S.H. Hepatoprotective activity of extracts from Pergularia daemia Forsk. against carbon tetrachloride-induced toxicity in rats Pharmacognosy Magazine 2007 3:11 (187-191) Picrorhiza kurrooa Phyllanthus amarusNaaz F., Javed S., Abdin M.Z. Hepatoprotective effect of ethanolic extract of Phyllanthus amarus Schum. et Thonn. on aflatoxin B1-induced liver damage in mice Journal of Ethnopharmacology 2007 113:3 (503-509)Chatterjee M., Sil P.C. Hepatoprotective effect of aqueous extract of Phyllanthus niruri on nimesulide-induced oxidative stress in vivo. Indian journal of biochemistry & biophysics 2006 43:5 (299-305) Plumbago zeylanicaKumar R., Kumar S., Patra A., Jayalakshmi S. Hepatoprotective activity of aerial parts of Plumbago zeylanica linn against carbon tetrachloride-induced hepatotoxicity in rats International Journal of Pharmacy and Pharmaceutical Sciences 2009 1:SUPPL. 1 (171-175) Card marià Silybum marianumBedi S., Goel A., Chand N., Rai J. A prospective study for evaluating the effect of Silymarin on hepatic functions in tubercular patients receiving DOTS Chest 2009 136:4 Scoparia dulcisHepatoprotective evaluation of Scoparia dulcis L. Sahoo A.K., Madhavan V. Journal of Complementary and Integrative Medicine 2009 6:1 Article Number 37 Salvia miltiorrhizaSong Y.-H., Liu Q., Lv Z.-P., Chen Y.-Y., Zhou Y.-C., Sun X.-G. Protection of a polysaccharide from Salvia miltiorrhiza, a Chinese medicinal herb, against immunological liver injury in mice International Journal of Biological Macromolecules 2008 43:2 (170-175)Lin Y.-L., Wu C.-H., Luo M.-H., Huang Y.-J., Wang C.-N., Shiao M.-S., Huang Y.-T. In vitro protective effects of salvianolic acid B on primary hepatocytes and hepatic stellate cells Journal of Ethnopharmacology 2006 105:1-2 (215-222) Scutellaria baicalensis Schisandra chinensisYip A.Y.S., Loo W.T.Y., Chow L.W.C. Fructus Schisandrae (Wuweizi) containing compound in modulating human lymphatic system - a Phase I minimization clinical trial Biomedicine and Pharmacotherapy 2007 61:9 SPEC. ISS. (588-590) Terminalia catappaKinoshita S., Inoue Y., Nakama S., Ichiba T., Aniya Y. Antioxidant and hepatoprotective actions of medicinal herb, Terminalia catappa L. from Okinawa Island and its tannin corilagin Phytomedicine 2007 14:11 (755-762)Subasini U., Rajamanickam G.V., Dubey G.P., Prabu P.C., Savariraj Sahayam C., Mohammed Shabi M., Gayathri K., Agrawal A. Hydroalcoholic extract of Terminalia arjuna: A potential hepatoprotective herb Journal of Biological Sciences 2007 7:2 (255-262) Tinospora cordifolia Zizyphus mauritianaAdhvaryu M.R., Reddy N., Parabia M.H. Effects of four Indian medicinal herbs on Isoniazid-, Rifampicin- and Pyrazinamide-induced hepatic injury and immunosuppression in guinea pigs World Journal of Gastroenterology 2007 13:23 (3199-3205) Vitis thunbergii, V. flexuosa, and V. kelungensis - three common wild grapes from TaiwanPhytocompounds from Vitis kelungensis stem prevent carbon tetrachloride-induced acute liver injury in mice Huang C.-C., Tung Y.-T., Cheng K.-C., Wu J.-H. Food Chemistry 2011 125:2 (726-731) Paeonia lactiflora i Astragalus membranaceus:- L'extracte de les arrels de P. lactiflora i A. membranaceus amb millor activitat que les plantes usades individualment.Sun W.-Y., Wei W., Gui S.-Y., Wu L., Wang H. Protective effect of extract from Paeonia lactiflora and Astragalus membranaceus against liver injury induced by Bacillus Calmette-Guérin and lipopolysaccharide in mice Basic and Clinical Pharmacology and Toxicology 2008 103:2 (143-149) De la medicina xinesa tradicional:-. Simo Yin, Guizhi Fuling Wan, Xieqing Wan, and Sini San.Lin K., Chen J., Tsauer W., Lin C., Lin J., Tsai C.-C. Prophylactic effect of four prescriptions of traditional Chinese medicine on α-naphthylisothiocyanate and carbon tetrachloride induced toxicity in rats Acta Pharmacologica Sinica 2001 22:12 (1159-1167) Plantes ayurvèdiques (30)Martha B.R. "Overview of certain Ayurvedic herbs in the management of hepatitis B: A clinical study" Hepatology Research 2010 40:7 (750)
Vegeu també Hepatotoxicitat
Referències
Categoria:Hepatologia