Intermediários metabólicos são moléculas que são os precursores ou metabólitos de moléculas biologicamente significantes.David L. Nelson; Michael M. Cox (2005). Principles of Biochemistry (IV Ed.). New York: W. H. Freeman. ISBN 0-7167-4339-6.Donald Voet; Judith G. Voet (2011). Biochemistry (IV Ed.). Wiley. ISBN 9780470917459.
Embora esses intermediários sejam de importância relativamente menor para a função celular, eles podem desempenhar papéis importantes na regulação alostérica de enzimas.Christian M. Metallo and Matthew G. Vander Heiden; Understanding metabolic regulation and its influence on cell physiology; Mol Cell. 2013 Feb 7; 49(3): 388–398. doi: 10.1016/j.molcel.2013.01.018
Significância clínica
Alguns podem ser úteis para medir taxas de processos metabólicos (por exemplo, ácido 3,4-di-hidroxifenilacético ou 3-aminobutirato).G. F. MURPHY, D. ROBINSON AND D. F. SHARMAN; The effect of tropolone on the formation of 3,4-dihydroxyphenylacetic acid and 4-hydroxy3-methoxyphenylacetic acid in the brain of the mouse; Br. J. Pharmac. (1969), 36, 107- 115.Wagner, J. , Vitali, P. , Palfreyman, M. G., Zraika, M. and Huot, S. (1982), Simultaneous Determination of 3,4‐Dihydroxyphenylalanine, 5‐Hydroxytryptophan, Dopamine, 4‐Hydroxy‐3‐Methoxyphenylalanine, Norepinephrine, 3,4‐Dihydroxyphenylacetic Acid, Homovanillic Acid, Serotonin, and 5‐Hydroxyindoleacetic Acid in Rat Cerebrospinal Fluid and Brain by High‐Performance Liquid Chromatography with Electrochemical Detection. Journal of Neurochemistry, 38: 1241-1254. doi:10.1111/j.1471-4159.1982.tb07897.xAriel Y.Deutch, See-Ying Tam, Robert H.Roth; Footshock and conditioned stress increase 3, 4-dihydroxyphenylacetic acid (DOPAC) in the ventral tegmental area but not substantia nigra; Brain Research, Volume 333, Issue 1, 29 April 1985, Pages 143-146Showing metabocard for 3-Aminoisobutanoic acid (HMDB0003911) - HMDBBrown DG, Rao S, Weir TL, O'Malia J, Bazan M, Brown RJ, Ryan EP: Metabolomics and metabolic pathway networks from human colorectal cancers, adjacent mucosa, and stool. Cancer Metab. 2016 Jun 6;4:11. doi: 10.1186/s40170-016-0151-y. eCollection 2016. PubMed:27275383Goedert JJ, Sampson JN, Moore SC, Xiao Q, Xiong X, Hayes RB, Ahn J, Shi J, Sinha R: Fecal metabolomics: assay performance and association with colorectal cancer. Carcinogenesis. 2014 Sep;35(9):2089-96. doi: 10.1093/carcin/bgu131. Epub 2014 Jul 18. PubMed:25037050Pollitt RJ, Green A, Smith R: Excessive excretion of beta-alanine and of 3-hydroxypropionic, R- and S-3-aminoisobutyric, R- and S-3-hydroxyisobutyric and S-2-(hydroxymethyl)butyric acids probably due to a defect in the metabolism of the corresponding malonic semialdehydes. J Inherit Metab Dis. 1985;8(2):75-9. PubMed:3939535
Porque podem representar pontos de entrada não naturais em vias metabólicas naturais, alguns (tais como ribonucleotídeo AICA) são de interesse para pesquisadores no desenvolvimento de novas terapias.Corton JM, Gillespie JG, Hawley SA, Hardie DG. 5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells? Eur J Biochem 229:558–565(1995)Galinanes M, Bullough D, Mullane KM, Hearse DJ. Sustained protection by acadesine against ischemia- and reperfusion-induced injury. Studies in the transplanted rat heart.Circulation 86:589–597 (1992)Zarembo, Alan. "'Exercise pill' could take the work out of workouts." Los Angeles Times. 01 08 2008, n. pag. Web. 21 Jan. 2012.
Leituras recomendadas
H. Stephen Stoker; Organic and Biological Chemistry; Cengage Learning, 2012.
Mary Campbell, Shawn Farrell; Biochemistry; Cengage Learning, 2007.
Ver também
Metabolismo
Categoria:Metabolismo