Retigabin je organsko jedinjenje, koje sadrži 16 atoma ugljenika i ima molekulsku masu od 303,331 -{Da}-.-{Porter RJ, Nohria V, Rundfeldt C: Retigabine. Neurotherapeutics. }--{Hermann R, Ferron GM, Erb K, Knebel N, Ruus P, Paul J, Richards L, Cnota HP, Troy S: Effects of age and sex on the disposition of retigabine. Clin Pharmacol Ther. }--{Hermann R, Knebel NG, Niebch G, Richards L, Borlak J, Locher M: Pharmacokinetic interaction between retigabine and lamotrigine in healthy subjects. Eur J Clin Pharmacol. . Epub 2003 Feb 28. }--{Dost R, Rostock A, Rundfeldt C: The anti-hyperalgesic activity of retigabine is mediated by KCNQ potassium channel activation. Naunyn Schmiedebergs Arch Pharmacol. . Epub 2004 Mar 9. }--{Mikkelsen JD: The KCNQ channel activator retigabine blocks haloperidol-induced c-Fos expression in the striatum of the rat. Neurosci Lett. }--{Punke MA, Friederich P: Retigabine stimulates human KCNQ2/Q3 channels in the presence of bupivacaine. Anesthesiology. }--{Wuttke TV, Seebohm G, Bail S, Maljevic S, Lerche H: The new anticonvulsant retigabine favors voltage-dependent opening of the Kv7.2 (KCNQ2) channel by binding to its activation gate. Mol Pharmacol. . Epub 2005 Jan 20. }--{Fatope MO: Retigabine (ASTA Medica). IDrugs. }--{Orhan G, Wuttke TV, Nies AT, Schwab M, Lerche H: Retigabine/Ezogabine, a KCNQ/K(V)7 channel opener: pharmacological and clinical data. Expert Opin Pharmacother. .. Epub 2012 Jul 12. }--{Amabile CM, Vasudevan A: Ezogabine: a novel antiepileptic for adjunctive treatment of partial-onset seizures. Pharmacotherapy. .. }- Osobine
Osobina Vrednost Broj akceptora vodonika 4 Broj donora vodonika 3 Broj rotacionih veza 6 Particioni koeficijent (-{ALogP)}- 2,8 Rastvorljivost (-{logS, log(mol/L}-)) -4,3 Polarna površina (-{PSA}-, Å2) 76,4
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-{Retigabine}-
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