CCL13

Hemokinski (C-C motivni) ligand 13 (CCL13) jest mali citokin koji pripada porodici CC hemokina. Njegov gen nalazi se na ljudskom hromosomu 17 unutar velike grupe drugih CC-hemokina.Garcia-Zepeda EA, et al.. Human monocyte chemoattractant protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophils, and basophils induced in allergic and no allergic inflammation that signals through the CC chemokine receptors (CCR)-2 and -3. J Immunol. 1996;157:5613–5626Naruse et al., A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2. Genomics. 1996, 34(2):236-40. CCL13 inducira hemotaksiju u monocitima, eozinofilima, T-limfocitima i bazofilima, vezanjem G-proteina na ćelijskoj površini, preko hemokinskih receptora, kao što su CCR2, CCR3 i CCR5.Blanpain et al., CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist. Blood. 1999, 94:1899-905. Aktivnost ovog hemokina uključena je u alergijske reakcije kao što je astma.Lamkhioued et al., Monocyte chemoattractant protein (MCP)-4 expression in the airways of patients with asthma. Induction in epithelial cells and mononuclear cells by proinflammatory cytokines. Am J Respir Crit Care Med. 2000, 162:723-32. CCL13 mogu inducirati upalni citokini interleukin-1 i TNF-α.

Aminokiselinska sekvenca Dužina polipeptidnog lanca je 98 aminokiselina, a molekulska težina 10.986 Da. 1020304050 MKVSAVLLCLLLMTAAFNPQGLAQPDALNVPSTCCFTFSSKKISLQRLKS YVITTSRCPQKAVIFRTKLGKEICADPKEKWVQNYMKHLGRKAHTLKT Simboli

C: Cistein D: Asparaginska kiselina E: Glutaminska kiselina F: Fenilalanin G: Glicin H: Histidin I: Izoleucin K: Lizin L: Leucin M: Metionin N: Asparagin P: Prolin Q: Glutamin R: Arginin S: Serin T: Treonin V: Valin W: Triptofan Y: Tirozin

Reference

Kategorija:Citokini Kategorija:Geni na hromosomu 17 Kategorija:Ljudski proteini Kategorija:Proteomika