Srebro diamin fluorid je topikalni lek koji se koristi za tretiranje i prevenciju karijesa i olakšavanje dentiske hiperzenzitivnosti. Srebro diamin fluorid je već decenijama dostupan u mnogim zemljama uključujući Kinu, Japan, Novi Zeland, Australiju i druge. Ovaj proizvod je FDA odobrila za prodaju u SAD u avgustu 2014 kao medicinsko sredstvo klase II za tretiranje dentinske hipersenzitivnosti.http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfpmn/pmn.cfm?ID=K102973
Klinička evidencija Šest randomizovanih kliničkih ispitivanja potvrđuju znatnu delotvornost ovog materijala u zatvaranju šupljina zuba, jednostavnim sušenjem šupljine i unosom ovog materijal.Chu CH, Lo ECM, Lin HC. Effectiveness of silver diamine fluoride and sodium fluoride varnish in arresting dentin caries in Chinese pre-school children. Journal of Dental Research. 2002;81(11):767-770.Lo EC, Chu CH, Lin HC. A community-based caries control program for pre-school children using topical fluorides: 18-month results. Journal of Dental Research. 2001;80(12):2071-2074.Llodra JC, Rodriguez A, Ferrer B, Menardia V, Ramos T, Morato M. Efficacy of silver diamine fluoride for caries reduction in primary teeth and first permanent molars of schoolchildren: 36-month clinical trial. Journal of Dental Research. 2005;84(8):721-724.Yee R, Holmgren C, Mulder J, Lama D, Walker D, van Palenstein Helderman W. Efficacy of silver diamine fluoride for Arresting Caries Treatment. Journal of Dental Research. 2009;88(7):644-647.Zhi QH, Lo ECM, Lin HC. Randomized clinical trial on effectiveness of silver diamine fluoride and glass ionomer in arresting dentine caries in preschool children. Journal of Dentistry. 2012;40(11):962-967. 2012;62(1):47-51.Zhang W, McGrath C, Lo ECM, Li JY. Silver diamine fluoride and education to prevent and arrest root caries among community-dwelling elders. Caries Res. 2013;47(4):284-290.
Dva randomizovana klinička ispitivanja potvrđuju efekte ovog leka u prevenciji formiraja šupljina, primenom na površine koje imaju šušljine. Četiri randomizovana klinička ispitivanja su potvrdila znatan impakt u sprečavanju formiranja šušljina.Tan HP, Lo ECM, Dyson JE, Luo Y, Corbet EF. A randomized trial on root caries prevention in elders. Journal of Dental Research. 2010;89(10):1086-1090.Liu BY, Lo ECM, Chu CH, Lin HC. Randomized trial on fluorides and sealants for fissure caries prevention. Journal of Dental Research. 2012;91(8):753-758.Monse B, Heinrich-Weltzien R, Mulder J, Holmgren C, van Palenstein Helderman WH. Caries preventive efficacy of silver diammine fluoride (SDF) and ART sealants in a school-based daily fluoride toothbrushing program in the Philippines. BMC Oral Health. 2012;12(1):52.
Nomenklatura Razlike u nomenklaturi su dovodile do zabune. Srebro diamin fluorid je takođe poznat kao: srebro fluorid, srebro diamin fluorid, diamin srebro fluorid, amonijačni srebro fluorid
Reference
Категорија:Стоматологија Категорија:Антимикробни лекови Категорија:Једињења сребра Категорија:Флуориди