Protein 13D pridružen vakuolskom sortiranju jest protein koji je kod ljudi kodiran genom VPS13D sa hromosoma 1.
Aminokiselinska sekvenca Dužina polipeptidnog lanca je 4.388 aminokiselina, a molekulska težina 491.916 Da.
1020304050 MLEGLVAWVLNTYLGKYVNNLNTDQLSVALLKGAVELENLPLKKDALKEL ELPFEVKAGFIGKVTLQIPFYRPHVDPWVISISSLHLIGAPEKIQDFNDE KEKLLERERKKALLQALEEKWKNDRQQKGESYWYSVTASVVTRIVENIEL KIQDVHLRFEDGVTNPSHPFAFGICIKNVSMQNAVNEPVQKLMRKKQLDV AEFSIYWDVDCTLLGDLPQMELQEAMARSMESRSHHYVLEPVFASALLKR NCSKKPLRSRHSPRIDCDIQLETIPLKLSQLQYRQIMEFLKELERKERQV KFRRWKPKVAISKNCREWWYFALNANLYEIREQRKRCTWDFMLHRARDAV SYTDKYFNKLKGGLLSTDDKEEMCRIEEEQSFEELKILRELVHDRFHKQE ELAESLREPQFDSPGACPGAPEPGGGSGMLQYLQSWFPGWGGWYGQQTPE GNVVEGLSAEQQEQWIPEEILGTEEFFDPTADASCMNTYTKRDHVFAKLN LQLQRGTVTLLHKEQGTPQMNESAFMQLEFSDVKLLAESLPRRNSSLLSV RLGGLFLRDLATEGTMFPLLVFPNPQKEVGRVSQSFGLQTTSADRSDHYP AADPDGPVFEMLYERNPAHSHFERRLNVSTRPLNIIYNPQAIKKVADFFY KGKVHTSGFGYQSELELRVAEAARRQYNKLKMQTKAEIRQTLDRLLVGDF IEESKRWTVRLDISAPQVIFPDDFKFKNPVLVVVDLGRMLLTNTQDNSRR KSRDGSASEETQFSDDEYKTPLATPPNTPPPESSSSNGEKTPPFSGVEFS EEQLQAHLMSTKMYERYSLSFMDLQIMVGRVKDNWKHVQDIDVGPTHVVE KFNVHLQLERRLIYTSDPKYPGAVLSGNLPDLKIHINEDKISALKNCFAL LTTPEMKTSDTQIKEKIFPQEEQRGSLQDSVMNLTQSIVLLEQHTREVLV ESQLLLAEFKVNCMQLGVESNGRYISVLKVFGTNAHFVKRPYDAEVSLTV HGLLLVDTMQTYGADFDLLMASHKNLSFDIPTGSLRDSRAQSPVSGPNVA HLTDGATLNDRSATSVSLDKILTKEQESLIKLEYQFVSSECPSMNLDSTL QVISLQVNNLDIILNPETIVELIGFLQKSFPKEKDDLSPQPLMTDFERSF REQGTYQSTYEQNTEVAVEIHRLNLLLLRTVGMANREKYGRKIATASIGG TKVNVSMGSTFDMNGSLGCLQLMDLTQDNVKNQYVVSIGNSVGYENIISD IGYFESVFVRMEDAALTEALSFTFVERSKQECFLNLKMASLHYNHSAKFL KELTLSMDELEENFRGMLKSAATKVTTVLATKTAEYSEMVSLFETPRKTR EPFILEENEIYGFDLASSHLDTVKLILNINIESPVVSIPRKPGSPELLVG HLGQIFIQNFVAGDDESRSDRLQVEIKDIKLYSLNCTQLAGREAVGSEGS RMFCPPSGSGSANSQEEAHFTRHDFFESLHRGQAFHILNNTTIQFKLEKI PIERESELTFSLSPDDLGTSSIMKIEGKFVNPVQVVLAKHVYEQVLQTLD NLVYSEDLNKYPASATSSPCPDSPLPPLSTCGESSVERKENGLFSHSSLS NTSQKSLSVKEVKSFTQIQATFCISELQVQLSGDLTLGAQGLVSLKFQDF EVEFSKDHPQTLSIQIALHSLLMEDLLEKNPDSKYKNLMVSRGAPKPSSL AQKEYLSQSCPSVSNVEYPDMPRSLPSHMEEAPNVFQLYQRPTSASRKKQ KEVQDKDYPLTPPPSPTVDEPKILVGKSKFDDSLVHINIFLVDKKHPEFS SSYNRVNRSIDVDFNCLDVLITLQTWVVILDFFGIGSTADNHAMRLPPEG ILHNVKLEPHASMESGLQDPVNTKLDLKVHSLSLVLNKTTSELAKANVSK LVAHLEMIEGDLALQGSIGSLSLSDLTCHGEFYRERFTTSGEEALIFQTF KYGRPDPLLRREHDIRVSLRMASVQYVHTQRFQAEVVAFIQHFTQLQDVL GRQRAAIEGQTVRDQAQRCSRVLLDIEAGAPVLLIPESSRSNNLIVANLG KLKVKNKFLFAGFPGTFSLQDKESVPSASPTGIPKHSLRKTTSTEEPRGT HSQGQFTMPLAGMSLGSLKSEFVPSTSTKQQGPQPTLSVGQESSSPEDHV CLLDCVVVDLQDMDIFAAERHPREYSKAPEDSSGDLIFPSYFVRQTGGSL LTEPCRLKLQVERNLDKEISHTVPDISIHGNLSSVHCSLDLYKYKLIRGL LENNLGEPIEEFMRPYDLQDPRIHTVLSGEVYTCMCFLIDMVNVSLELKD PKRKEGAGSLARFDFKKCKLLYESFSNQTKSINLVSHSMMAFDTRYAGQK TSPGMTNVFSCIFQPAKNSSTTQGSIQIELHFRSTKDSSCFTVVLNNLRV FLIFDWLLLVHDFLHTPSDIKKQNHVTPSRHRNSSSESAIVPKTVKSGVV TKRSSLPVSNERHLEVKVNVTGTEFVVIEDVSCFDTNAIILKGTTVLTYK PRFVDRPFSGSLFGIEVFSCRLGNEHDTALSIVDPVQIQMELVGNSSYQN SSGLMDAFNSEDFPPVLEIQLQALDIRLSYNDVQLFLAIAKSIPEQANAA VPDSVALESDSVGTYLPGASRVGEEIREGTRHTLDPVLELQLARLQELGF SMDDCRKALLACQGQLKKAASWLFKNAEPLKSLSLASTSRDSPGAVAAPL ISGVEIKAESVCICFIDDCMDCDVPLAELTFSRLNFLQRVRTSPEGYAHF TLSGDYYNRALSGWEPFIEPWPCSVSWQQQAASRLHPPRLKLEAKAKPRL DINITSVLIDQYVSTKESWMADYCKDDKDIESAKSEDWMGSSVDPPCFGQ SLPLVYLRTRSTASLTNLEHQIYARAEVKTPKRRQPFVPFALRNHTGCTL WFATLTTTPTRAALSHSGSPGVVPEGNGTFLDDTHNVSEWREVLTGEEIP FEFEARGKLRHRHTHDLRIHQLQVRVNGWEQVSPVSVDKVGTFFRYAAPD KNSSSSTIGSPSSRTNIIHPQVYFSSLPPVRVVFAVTMEGSARKVITVRS ALIVRNRLETPMELRLDSPSAPDKPVVLPAIMPGDSFAVPLHLTSWRLQA RPKGLGVFFCKAPIHWTNVVKTAEISSSKRECHSMDTEKSRFFRFCVAIK KENYPDYMPSNIFSDSAKQIFRQPGHTIYLLPTVVICNLLPCELDFYVKG MPINGTLKPGKEAALHTADTSQNIELGVSLENFPLCKELLIPPGTQNYMV RMRLYDVNRRQLNLTIRIVCRAEGSLKIFISAPYWLINKTGLPLIFRQDN AKTDAAGQFEEHELARSLSPLLFCYADKEQPNLCTMRIGRGIHPEGMPGW CQGFSLDGGSGVRALKVIQQGNRPGLIYNIGIDVKKGRGRYIDTCMVIFA PRYLLDNKSSHKLAFAQREFARGQGTANPEGYISTLPGSSVVFHWPRNDY DQLLCVRLMDVPNCIWSGGFEVNKNNSFHINMRDTLGKCFFLRVEITLRG ATYRISFSDTDQLPPPFRIDNFSKVPVVFTQHGVAEPRLRTEVKPMTSLD YAWDEPTLPPFITLTVKGAGSSEINCNMNDFQDNRQLYYENFIYIAATYT FSGLQEGTGRPVASNKAITCAELVLDVSPKTQRVILKKKEPGKRSQLWRM TGTGMLAHEGSSVPHNPNKPSAARSTEGSAILDIAGLAAVTDNRYEPLML RKPDRRRSTTQTWSFREGKLTCGLHGLVVQAKGGLSGLFDGAEVVLGPDT SMELLGPVPPEQQFINQKMRPGSGMLSIRVIPDGPTRALQITDFCHRKSS RSYEVDELPVTEQELQKLKNPDTEQELEVLVRLEGGIGLSLINKVPEELV FASLTGINVHYTQLATSHMLELSIQDVQVDNQLIGTTQPFMLYVTPLSNE NEVIETGPAVQVNAVKFPSKSALTNIYKHLMITAQRFTVQIEEKLLLKLL SFFGYDQAESEVEKYDENLHEKTAEQGGTPIRYYFENLKISIPQIKLSVF TSNKLPLDLKALKSTLGFPLIRFEDAVINLDPFTRVHPYETKEFIINDIL KHFQEELLSQAARILGSVDFLGNPMGLLNDVSEGVTGLIKYGNVGGLIRN VTHGVSNSAAKFAGTLSDGLGKTMDNRHQSEREYIRYHAATSGEHLVAGI HGLAHGIIGGLTSVITSTVEGVKTEGGVSGFISGLGKGLVGTVTKPVAGA LDFASETAQAVRDTATLSGPRTQAQRVRKPRCCTGPQGLLPRYSESQAEG QEQLFKLTDNIQDEFFIAVENIDSYCVLISSKAVYFLKSGDYVDREAIFL EVKYDDLYHCLVSKDHGKVYVQVTKKAVSTSSGVSIPGPSHQKPMVHVKS EVLAVKLSQEINYAKSLYYEQQLMLRLSENREQLELDS
Funkcija Ovaj gen kodira protein koji pripada porodici gena vakuolskih-sortirajućih proteina-13. U kvascima, vakuolno-protein-sortirajući-13 proteini uključeni su u promet membranskih proteina između trans-Golgi jeve mreže i prevakuolskog odjeljka.
Iako za ovaj gen može postojati nekoliko varijanti transkripta, do danas su opisane pune prirode samo dvije. Ova dva predstavljaju glavne varijante ovog gena i kodiraju različite izoforme.
Reference
Dopunska literatura
Kategorija:Geni na hromosomu 1 Kategorija:Ljudski proteini Kategorija:Proteomika